Tools for protein networks building

Question

[Bnf83]

Hi guys, I need to create a network of interacting proteins from MS expression measurements. Do you know which tools, softwares and algorithms are available to do this?

Thank you in advance

[Benn]

Don't you need interaction data, instead of expression data, in order to do this? Like yeast two hybrid for instance?

[Bnf83]

Hi. I only have protein expression data from a MS experiment.

Answer 1

[natasha.sernova]

Look at this paper:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086107/

NetworkAnalyst - integrative approaches for protein–protein interaction network analysis and visual exploration

Answer 2

[jiwpark00]

You can use Cytoscape. Granted, you are going to first need interaction data - which proteins are already interacting with what, etc.. Then you can use your expression data as a way to weigh the strength of each interaction.

Answer 3

[Bnf83]

Thank you very much guys!