Bipolar disorder(Manic Depressive Illness)

Question

[ayeshasahar]

Hii I am working on bipolar disorder.My protein is Glycogen synthase kinase-3 beta.I found 25 inhibitors against this disease from med chem website and from Literature. Kindly guide me some other tool or website to get other ligands specifically involved in GSK-3 beta inhibition and also suggest me the screening libraries for virtual screening.

[Donita Antashari]

Can you explain sign of bipolar illnes ? Thank you

Answer 1

[Denise CS]

Have you tried the Target Validation Platform? You can search for either the disease or gene. Starting with the disease, you can get the list of all 1266 targets associated with bipolar disorder, then focus on your GSK3 to find the Evidence for GSK3B in bipolar disorder, or explore more the gene itself (GSK3) or the disease itself. Check the docs About the Target Validation Platform, the frequently asked questions and the data sources used to associate Gene A with Disease B.