Function createTissueSpecificModel from Cobra Toolbox with E.coli model iJO1366
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8.0 years ago
TS ▴ 30

Dear biostars forum,

I have a question I already asked in the cobra toolbox google group but I didn't get an answer, so I try it here now.

I am trying to use the Cobra toolbox function createTissueSpecificModel (see here) with the E.coli model iJO1366. My goal is to get create different tissue models from the data from this Agilent singel-color microarray experiment.

I was able to get a presence/absence call for each  gene on the microarray and build the expressionData structure with the Data and the Locus.

Now my question: my struct expression contains the 2 vectors Locus (1228x1 cell) und Data (1228x1 double) with Locus containing E.coli GeneIDs (e.g. 'b0002', 'b0003'). and Data containing 1 and 0.

Is it still possible for me to use createTissueSpecificModel with this model and my struct expressionData?

Kind regards, Thomas

Cobra toolbox createTissueSpecificModel iJO1366 • 1.7k views
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