To understand the purpose of different tools
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8.0 years ago

Hi,

I am using SRA reads to identify the roles of the intergenic regions I have isolated using the perl script. I have very moderate understanding of the output and purposes of different tools. So far I used bowtie to align the SRA reads to my reference genome and then cufflinks to get the expression value for each gene. I do not understand now how can I relate the intergenic regions to the SRA read expression output of cufflinks.For cufflinks I have four output as:genes.fpkm_tracking isoforms.fpkm_tracking skipped.gtf transcripts.gtf

For my understanding I looked for the expression value of genes.fpkm_tracking. Now from this point I do not have any idea how to relate my output to the intergenic regions. My genes.fpkm_tracking output looks like this:

gene0   -       -       gene0   -       -       NC_000921.1:50-467      -       -       9.31549 6.41812 12.2129 OK
gene1   -       -       gene1   -       -       NC_000921.1:468-939     -       -       5.89251 3.80506 7.97995 OK
CUFF.1  -       -       CUFF.1  -       -       NC_000921.1:948-2431    -       -       23.5725 20.3547 26.7902 OK
gene27  -       -       gene27  -       -       NC_000921.1:26314-27595 -       -       52.0518 48.7694 55.3342 OK
CUFF.2  -       -       CUFF.2  -       -       NC_000921.1:27752-31609 -       -       54.1168 48.789  59.4447 OK
CUFF.3  -       -       CUFF.3  -       -       NC_000921.1:29641-31999 -       -       0       0       0       OK
gene32  -       -       gene32  -       -       NC_000921.1:32110-32524 -       -       3.58937 1.79469 5.38406 OK
CUFF.4  -       -       CUFF.4  -       -       NC_000921.1:32525-35369 -       -       20.8448 14.6654 27.0242 OK
CUFF.5  -       -       CUFF.5  -       -       NC_000921.1:35371-37741 -       -       12.1854 10.3385 14.0322 OK
CUFF.6  -       -       CUFF.6  -       -       NC_000921.1:37756-44757 -       -       6.01506 4.82217 7.20795 OK
gene46  -       -       gene46  -       -       NC_000921.1:44708-45005 -       -       0       0       0       OK
gene47  -       -       gene47  -       -       NC_000921.1:45189-46188 -       -       0.615931        0.20531 1.02655 OK
CUFF.7  -       -       CUFF.7  -       -       NC_000921.1:46190-49432 -       -       9.48516 8.15957 10.8108 OK
CUFF.8  -       -       CUFF.8  -       -       NC_000921.1:49490-50718 -       -       5.19769 3.40986 6.98552 OK
gene52  -       -       gene52  -       -       NC_000921.1:51151-52183 -       -       21.3319 18.946  23.7178 OK
gene53  -       -       gene53  -       -       NC_000921.1:52192-52975 -       -       6.08926 4.5605  7.61801 OK
gene54  -       -       gene54  -       -       NC_000921.1:53402-54893 -       -       82.8641 79.0848 86.6433 OK
gene55  -       -       gene55  -       -       NC_000921.1:54919-58477 -       -       12.9985 12.0592 13.9377 OK
gene56  -       -       gene56  -       -       NC_000921.1:58797-59007 -       -       1128.22 1063.83 1192.61 OK
gene57  -       -       gene57  -       -       NC_000921.1:59334-59997 -       -       0       0       0       OK
gene58  -       -       gene58  -       -       NC_000921.1:60126-60489 -       -       0       0       0       OK
gene59  -       -       gene59  -       -       NC_000921.1:60489-61473 -       -       2.5784  1.72187 3.43493 OK
gene60  -       -       gene60  -       -       NC_000921.1:61483-61915 -       -       0       0       0       OK
gene61  -       -       gene61  -       -       NC_000921.1:62095-63664 -       -       0       0       0       OK
gene62  -       -       gene62  -       -       NC_000921.1:63897-64467 -       -       0.280373        0       0.677432        OK
gene63  -       -       gene63  -       -       NC_000921.1:64482-64743 -       -       0       0       0       OK
CUFF.9  -       -       CUFF.9  -       -       NC_000921.1:64753-66645 -       -       0.256232        0       0.61988 OK
CUFF.10 -       -       CUFF.10 -       -       NC_000921.1:66649-69413 -       -       0       0       0       OK
CUFF.11 -       -       CUFF.11 -       -       NC_000921.1:71719-76714 -       -       118.293 112.861 123.725 OK
CUFF.12 -       -       CUFF.12 -       -       NC_000921.1:69486-77636 -       -       0       0       0       OK
gene78  -       -       gene78  -       -       NC_000921.1:77725-77995 -       -       22.9369 16.2247 29.6491 OK
gene79  -       -       gene79  -       -       NC_000921.1:78113-79172 -       -       45.6573 42.2265 49.0881 OK

Please, help me with this. Regards, Bandana

RNA-Seq rna-seq gene sequencing • 1.2k views
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To me it's unclear what you aim to achieve... Perhaps you should read the manual and follow a tutorial to get a better idea of what you are doing and what the purpose of the tools is.

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