Forum:What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2016?

Question

[dago]

A new year just finished and many new exciting discoveries/programs/methods have been published.

In consistency with previous Discussions

• What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2014?
• What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2011?
• Best Papers On Computational Biology From 2010
• What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2015?

What do you think were the most influential Bioinformatics/Computational Biology Papers/methods/discovery Of 2016?

[GenoMax]

So far 20 upvotes in total but only one actual answer.

Answer 1

[brentp]

Certainly the ExAC paper: http://www.nature.com/nature/journal/v536/n7616/full/nature19057.html must be one of the top.

published in August and cited > 200 times already.

It's a game-changer for rare disease.

[WouterDeCoster]

Actually, first published/posted in October 2015 (damn that took long to get it out) http://biorxiv.org/content/early/2015/10/30/030338

Answer 2

[Diwan]

If popular 2016 papers might be of interest too, here is a list of popular 2016 articles in BMC Systems biology: http://blogs.biomedcentral.com/bmcseriesblog/2017/01/13/bmc-systems-biology-2016-review/

Articles in the list are:

1. Systems biology of the structural proteome. http://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-016-0271-6

2. Feedback control in planarian stem cell systems. http://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-016-0261-8

3. Comparing Alzheimer’s and Parkinson’s diseases networks using graph communities structure. http://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-016-0270-7

4. Where next for the reproducibility agenda in computational biology? http://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-016-0288-x

5. Integrating mutation and gene expression cross-sectional data to infer cancer progression. http://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-016-0255-6