openssl/hmac.h error while installing bedGraphToBigWig

Question

[biotech]

I'm trying to install bedGraphToBigWig into MACOSX.

I'm following this instructions:

https://github.com/ENCODE-DCC/kentUtils

I'm having this error when doing sudo make:

gcc -O -g  -Wall -Wno-unused-variable -Wno-deprecated-declarations  -D_FILE_OFFSET_BITS=64 -D_LARGEFILE_SOURCE -D_GNU_SOURCE -DMACHTYPE_local -DUSE_SSL -DCOLOR32 -DUSE_SAMTABIX -DUSE_BAM -DUSE_TABIX -DKNETFILE_HOOKS   -Wall -Wno-unused-variable -Wno-deprecated-declarations  -I../inc -I../../inc -I../../../inc -I../../../../inc -I../../../../../inc -I/include -I/usr/local/Cellar/libpng/1.6.25/include/libpng16 -I/Users/bernardo/Desktop/2017_02_13_Babitzke/whole_trimmed/kentUtils/samtabix  -o hmac.o -c hmac.c
hmac.c:12:10: fatal error: 'openssl/hmac.h' file not found
#include "openssl/hmac.h"
         ^
1 error generated.
make[2]: *** [hmac.o] Error 1
make[1]: *** [topLibs] Error 2
make: *** [libs] Error 2

What should I do?

I tried:

051894:kentUtils bernardo$ brew install openssl
Warning: openssl is a keg-only and another version is linked to opt.
Use `brew install --force` if you want to install this version

Answer 1

[GenoMax]

Why not download pre-compiled bedGraphToBigWig executable for macOS here. Remember to do chmod u+x bedGraphToBigWig afterwards.

[biotech]

What is http://hgdownload.cse.ucsc.edu?

[GenoMax]

It is the site to download data/tools from UCSC.

Answer 2

[Alex Reynolds]

OS X doesn't use OpenSSL any longer. You can still compile things but it is more work. Use the precompiled versions of Kent utilities.

[biotech]

What are Kent utilities?

[Alex Reynolds]

They are what you are trying to install ("kentUtils").