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7.7 years ago
riyaannmathews
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0
i want to replace the GO ids from a file with their respective gene symbols from another file using R.But a particular GO id has 3-4 gene symbols.What parameter should i use to select the gene symbol?
GO terms are not unique to genes. Therefore one gene can have many assigned GO terms and likewise a GO term can be associated with many genes. A 1:1 mapping will not work. Could you be a bit more specific about what you are trying to do?
i have a list of GO ids with their corelation values and another file with the same GO ids with their gene symbols.I want to replace the GO ids in the first file with their respective gene symbols from the second. and these gene symbols are to be used for performing cytoscape.As the available GO terms are associated with many genes,what parameter should i adopt to select the genes?
Since you performed the correlation on the GO ids I don't think you can use the Go ids as a proxy for gene symbol. There is a way to merge the the terms and gene symbols using the plyr and reshape packages but since you don't know which gene 'gave' the GO term you can't go from GO to gene and maintain any kind of significance.