Is it safe to assume that a sequence assigned to a particular COG ID in an old version of eggNOG is related to sequences assigned to that same COG ID in the latest version?
In more detail, I would like to fund the ‘COG functional category’ for some eggNOG COG IDs retrieved from UniProtKB (e.g. www.uniprot.org/uniprot/F0YY04.txt) However, I don’t know the version of eggNOG that these COG IDs were created under. I am wondering if I can safely use the COG-functional mapping provided in the latest version of eggNOG (v4.5) to infer the function of my UniProt sequences.
I am aware that I could query the UniProt sequences against the latest version of eggNOG, but this would be much more time consuming than using the available mappings supplied by UniProtKB.
Many thanks
see this: A: What are those "ENOG" numbers in eggNOG 4.5?