Gene Body methylation

Question

[niutster]

Hi,

Has gene body methylation effect on its expression? As i know GpG Islands, Shores and regions such as these have great effect on gene expression.

Answer 1

[EagleEye]

This is an article where it shows gene body methylation has opposite effect on gene expression compared to promoter methylation.

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

This is the article where they show it in more systematic way.

Answer 2

[Devon Ryan]

Yes, gene body methylation (at least in some cases) seems to stabilize transcription, thereby increasing expression.

[zjhzwang]

So does it means that methylation can cause not only negative effect but also positive effect?

[Devon Ryan]

Correct, promoter methylation will generally decrease expression while gene body methylation will generally increase it.

[ivivek_ngs]

does not it also refer to if the methylation is hyper or hypo? based on that the expression of the gene is more or less active or repressed?

[Devon Ryan]

In this context, "methylation" will always be "hypermethylation".