Question

p value notation

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7.5 years ago

Gene_MMP8 ▴ 240

I am currently reading a paper that employs machine learning based techniques to predict driver mutations. In this paper, it is written that, this method is highly enriched with known drivers, (p<10^-14). Can someone explain to me the significance of p value in this case?
here is the link to the paper. Look under the Summary portion and you will find the p value reference.
(Disclosure: I have minimal background in statistics).
Thank you.

R genome • 1.3k views

ADD COMMENT • link updated 7.5 years ago by Istvan Albert 101k • written 7.5 years ago by Gene_MMP8 ▴ 240

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Could you post a link?

ADD REPLY • link 7.5 years ago by russhh 5.7k

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Updated my question with the link. Can you please check?

ADD REPLY • link 7.5 years ago by Gene_MMP8 ▴ 240

score 0 · Answer 1 · 2017-05-24

The p-value always has the same interpretation - the chance of obtaining a result equal to or more extreme than what was actually observed.

https://en.wikipedia.org/wiki/P-value

That being said the actual definition and interpretation are a little more complicated and the concept itself commonly and ubiquitously misunderstood and misused:

https://en.wikipedia.org/wiki/Misunderstandings_of_p-values#Common_misunderstandings_of_p-values