How to characterize synonymous and non-synonymous substitution from variants data

Question

[adeena_hassan]

Assalam o alikum everyone

I have vcf files of dog genome which contains variants data and i want to characterize synonymous and non-synonymous substitutions from these variants. Any advice how to do so? kindly tell me is there any tool ?

I am new in this field so happy to give more info Thanks in advance Adeena

Answer 1

[Medhat]

please read this answer it will help:
A: Synonymous And Non-Synonymous Snps

after reading that, you could annotate your SNPs using for example:
VEP or SnpEff
both tool are very convenient

[adeena_hassan]

Thank u so much ,, its helpful