Entering edit mode
7.5 years ago
prasundutta87
▴
670
Can anyone point me to a literature or explain the need of population priors during genotype likelihood estimation using RNAseq data? I did get results connected to DNAseq. I am using bcftools mpileup (v1.4) for likelihood estimation and then genotype calling and variant calling using bcftools call (v1.4).
Why would variant calling on RNAseq be any different than that on DNAseq data in this respect?