Nucleotide Repeats Associated With Cancer?

Question

[Elena]

Hi Friends,

Is there any repeats (short nucleotides like AT or GC or GATA repeats) which can be one of the factor for causing breast cancer? and is there any article regarding it?

[Michael Kuhn]

Could you please add some more information: Why do you think this might be the case? What part of the literature have you surveyed so far?

[Giovanni M Dall'Olio]

I have changed the title, check it out. The way you put it in the first place gave me the impression that you were asking whether repeats are the only responsible for cancer.

[User 59]

I don't think this is necessarily bioinformatics related.

[Elena]

actually it has been studied that Trinucleotide repeats affect DNA replication in vivo.

[User 59]

So please can you expand on the bioinformatics part of this question? Otherwise it will get closed as off topic. I still don't see how this can't be answered with a PubMed search.

[Elena]

as it has been studied that few repeats like CAG polymorphism causes breast cancer. So, if we find the repeats in a particular gene more in number, it means that the gene is highly prone to the disease.

Answer 1

[Bio_X2Y]

The following paper seems to be asking your question, and provides a review of known associations between short tandem repeat polymorphisms and breast cancer:

• Polymorphisms of short tandem repeat of genes and breast cancer susceptibility

EDIT: since you don't have access to that paper, here is a simplification of its Table 1, which summarises the genes with STR polymorphisms associated with breast cancer. Use with caution - I may have introduced errors or posted incorrect URLs. Also, remember to cite the authors if you use this information.

AR (Androgen Receptor)

• STR: (CAG)n
• Position: Exon 1
• References: 3, 4, 5, 6, 7, 8, 9

ER-alpha (Estrogen receptor 1)

• STR: (GT)n
• Position: Promoter
• References: 10, 11, 12

E2F-4 (E2F transcription factor 4)

• STR: (AGC)n
• Position: Exon 7
• References: 17

CYP19 (Cytochrome P450, family 19)

• STR: (TTTA)n
• Position: Intron 4
• References: 18, 19, 20, 21

CYP11A (Cytochrome P50, family 11)

• STR: (TAAAA)n
• Position: Promoter
• References: 22

IGF-1 (Insulin-like growth factor 1)

• STR: (CA)n
• Position: Promoter
• References: 1, 23, 24

AIB1 (Nuclear receptor cofactor 3)

• STR: (CAG)n
• Position: C-terminus coding region
• References: 25, 26, 27, 28, 29

IFNG (Interferon, gamma)

• STR: (CA)n
• Position: Intron 1
• References: 30

SMYD3 (SET and MYND domain containing protein 3)

• STR: (CCGCC)n
• Position: Promoter
• References: 31

ERBB-1 (Epidermal growth factor receptor)

• STR: (CA)n
• Position: Intron 1
• References: 32, 33, 34

[Elena]

Thanku @Bio_X2Y for the information

[Elena]

ya thanks for the article..

[Elena]

ya thanks for the article, but unable to download it.

Answer 2

[Anuraj Nayarisseri]

Access dbSNP and Study the all the snps of BRCA1 gene which is associated with Breast Cancer.