bioinformatics metagenomics analysis towards finding drug candidates

Question

[Quak]

I wonder what are the possibilities towards finding drug/metabolite candidates using metagenomics data. Metagenomics data only provides prokaryotic related data (well, there would be some host genome as well), I wonder what are the possibility to study host-metagenome interaction towards finding drug/metabolite candidates.

[h.mon]

Don't wonder, search.

Some potentially helpful reviews:

https://www.ncbi.nlm.nih.gov/pubmed/25614221

https://www.ncbi.nlm.nih.gov/pubmed/26791724

https://www.ncbi.nlm.nih.gov/pubmed/26379658

https://www.ncbi.nlm.nih.gov/pubmed/19903165

[Quak]

Thanks for sharing these links and sorry for not making it clear. I am more curious about the computational approaches on this matter rather than experimental efforts. e.g from geneX, in KEGG database, what are the reasonable practices one can take to generate a list of metabolite/protein candidates. How can I take the Gene sequence, look it up and see what enzyme/protein are transcribed. The same regarding metabolites.