How to filter out variants based on the population frequency

Question

[bioinforesearchquestions]

Hi All,

I have been asked to filter out variants based on the population frequency. In order to do this, should I use "AF-Allele Frequency" of my sample?

What is the significance of annotating VCF file with the allele frequency of ASN, AMR, AFR and EUR?

Answer 1

[shahimahdi57]

helo my friends,my english not very good but now i asswer you:we have very toos or site that you can use of them to filtering your data(vcf),for example population frequency,structure based,prediction,and evidence.and in population frequncy based you can use of 1000 genome project,NHLBI cohort and HAPMAP project....I hope I've been right my ansswer