Normalization of NGS data to make CNV calls

Question

[caspase8mach]

Hi Biostars Community,

I have low-coverage (~ 1X) WGS data for 5 disease and 5 controls samples. I want to make CNV calls using this data.

My question is, do I need to normalize reads for ALL the samples before making CNV calls? If so, could you please suggest an R package to do so!

Thanks a lot for the help.

Best regards, Akhil