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7.2 years ago
Nada
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10
Hi everyone..I am trying to search for the statistically significant mutated genes in my patients (WES), and I found that MUSIC tools are the recommended tools to perform this, and it works only on Linux. My question is:are there similar programs that work on Windows 7?? My other question: if I ever install Linux on my PC can I reverse it later to windows? and which Linux version should I install? Thanks
The easiest would be to simply get a separate harddrive for a Linux partition. Standard Ubuntu will do. Do yourself a favor and change to Linux right away, most bioinformatics software is Unix-based.
Thanks a lot for the rapid Reply ATPoint. 920 So the Standard Ubunto will be sufficient for all bioinformatic software???
Short answer is yes.
A further option to safely install linux would be to install is within a virtual machine; Besides allowing to use windows + linux more conveniently in parallel (e.g.: using software specific to either operating system), it also creates a safe environment to get familiar with linux https://www.virtualbox.org
If you are talking about using MuSiC from analyzing significantly mutated genes in cancer, then you should be aware that MuSiC has elevated false positives due to how their statistical model handles mutational heterogeneity (PMIDs: 27911828 (includes a method comparison), 23770567). This is particularly severe for high mutation rate cancers. You may need to implement a heavy amount of custom post-hoc filtering to ameliorate these problems, which would not be necessary for other methods.
Nonetheless, if you are interested in MuSiC then they have a biostars post on installing MuSiC (Installation of the MuSiC suite on unsupported Linux distributions ). In terms of installing MuSiC, the only way I could get it installed was through using docker as it is particularly finicky with a precise version of ubuntu. Their website lists Ubuntu 10.04 (an old version of ubuntu) as the official operating system. I've tried before on non-ubuntu linux distributions and it was virtually impossible to install without docker.