To find literature I use a set of different search engines (Pubmed, Google Scholar, ACM.org, etc). Sometimes directly at their website or through literature managers such as, Jabref and Mekentosj Papers. The latter is great, since it captures the pdf locally.
Then I use connotea, citeulike, and WikiPathways to order my collection. Recently I even started using twitter to manage literature annotations.
Still it happens, even often, that I "loose" papers. I know that I have read a paper, but I don't manage to find it again. I forgot under which label or where I had stored it, or even that I had annotated it.
With all the technology in place, I am still not able to track literature completely.
That is why I am looking for other approaches to optimize my literature management strategy.
A standalone zotero is being developed at the moment. Still alpha but looks exciting: http://www.zotero.org/blog/zotero-standalone-alpha-with-chrome-and-safari-support/
+1 for mendeley
+1 for mendeley. I made the switch from citeulike (mendeley allows importing) and it makes life way easier. You can create a watch dir and when new files are added to that dir mendeley sorts them. Groups and stuff are also useful.
@david w: thanks, I'll look at the zotero standalone app.
zotero! and in our group we have our own webdav-server. Easy to organize, easy to share with group. And also it lets you add the pdf-files so you can access at home ;-)