What are some examples of non-homologous sequences having similar functions?

Question

[nafizh]

I am trying to find some proteins that are non-homologous but functionally similar. But cannot seem to find concrete examples. Can someone please point out any resources or provide examples?

Answer 1

[Kevin Blighe]

These are generally referred to as non-homologous, isofunctional proteins. One notable example is the cellulase family of proteins. There are some examples in the literature:

• Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

• Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

• Cellulases: ambiguous non-homologous enzymes in a genomic perspective

Answer 2

[lexa.matej]

This list of convergent evolution in protein function could come handy.