Drug pharmacological actions

Question

[kakukeshi]

Hello guys,

I got a list of drugs and I would like to collect information about their pharmacological actions. I'm especially interested to know if these drugs have for example anti-cancerous, cardioprotective, antioxidant or neuroprotective properties. The only resource that I found so far that explicitly show which of these actions are associated with each drug is the MeSH browser (https://meshb.nlm.nih.gov/search), but unfortunately, is not updated for some drugs.

Any database that you may recommend me? Thanks

[natasha.sernova]

Right now I've found this database:

http://www.kegg.jp/kegg/drug/

The authors described it in the file below:

http://giw.hgc.jp/giw2009/pdf/I02-Kanehisa.pdf

You will find a lot of information there.

See also this post and their drug database mentioned inside:

Indirect targets by merging Drug-Target and Protein-protein databases

Answer 1

[Kevin Blighe]

I imagine that the very top databases are private and not for public use. However, apart from the KEGG database mentioned by Natasha (above), two other great ones that come to mind include:

• Open PHACTS - https://www.openphacts.org/
• PharmGKB - https://www.pharmgkb.org/
• DGIdb - http://dgidb.org/

Also take a look at this publication on the topic: DGIdb: mining the druggable genome

Answer 2

[LLTommy]

Not exactly what you are looking for, but you should check it out anyway. https://www.opentargets.org/