SNP calling for whole genome bisulfite sequencing data as a quality control step
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7.0 years ago
cjgunase ▴ 50

Hi, we recently received WGBS data from 3 tissues in 10 individuals (30 samples). As a quality control measure, I want to check if any samples were got switched during tissue transfer. So I am planning to do SNP concordance to compare all 30 libraries. This should show high concordance within each individual.

Is this approach the best way to do this type of quality control or is there any other method?

Thank you

bisulfite-sequencing next-gen sequence • 1.3k views
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