Where all can I find Histone Modification data for certain Human and Mouse cells

Question

[Saad Khan]

Hi,

I am trying to look for Histone modification data for Human/Mouse. I was looking at following tissues and was wondering if this data might be available.Can anybody kindly point me to data for following tissues.

1. Cerebellum
2. Colon
3. Cortex
4. Heart
5. Intestine
6. Kidney
7. Liver
8. Lung
9. Olfactory bulb
10. Pancreas
11. Placenta
12. Skin
13. Spleen
14. Stomach
15. Thymus
16. Uterus

Regards

Answer 1

[Manvendra Singh]

you can look into NIH road epigenomic datasets, they have data in many formats whichever you like

http://www.roadmapepigenomics.org/data

http://www.ncbi.nlm.nih.gov/geo/roadmap/epigenomics/

even at NCBI

http://www.ncbi.nlm.nih.gov/epigenomics/

just give key words as Human or mouse + Histone + tissue

you would see their all deposited data

[Saad Khan]

But that data is not publicly available I believe.

[Manvendra Singh]

They are available for sure

e.g you give keywords ChIP-seq, histone modification, H3K36me3

It would lead to geo data set (lets say this one), then you can download raw files(.sra) or processed ones (.bed files)

[Saad Khan]

I tried the way you suggested.For most of these tissues in Mouse I could not find histone data.

[Manvendra Singh]

You can search on NCBI Geo to see what are histone data available

Answer 2

[moldach]

Histones and their modification in humans (mammals) can be found in several databases (in addition to ROADMAP) such as HIstome, Human Histone Modification Database, iHMS, HistoneDB, Histone Systematic Mutation Database, and WERAM