Software to analyse mutational signatures other than DeconstructSigs R package

Question

[peterodonovan]

I am currently researching mutational signatures in Cancer genomes (see here for an explanation: http://cancer.sanger.ac.uk/cosmic/signatures ). I am using the DeconstructSigs package in R to analyze the data I have available. I was just wondering, do there exist other software for performing the same task that are seen as better? I know of the existence of the SomaticSignatures package but am unclear whether it is any better or worse than DeconstructSigs.

Any advice would be greatly appreciated!

Answer 1

[poisonAlien]

There are few other tools. DeconstructSigs estimates loading of known signatures for every sample in the cohort. If you are interested in de-novo you could try EMu and Mutational Signature framework. Both from Sanger.