NCBI map viewer fragile site are molecularly characterized or not.

Question

[rajesh]

Hello everyone

In NCBI map viewer, there reported 127 fragile sites. can anyone have the idea that the all the fragile site listed in NCBI map viewer, are only cytogenetically defined (based on cytoband position) or they are cytogenetically defined with molecular characterized? Molecular characterization means that they are cloned at sequence level.

[tdmurphy]

I'm not familiar with a map of fragile sites in NCBI's (now retired) Map Viewer. What organism, assembly, and map name are you looking at? Can you provide a link for what you're referring to?

[rajesh]

Thanks for your answer Here is the link of NCBI map viewer of human fragile site https://www.ncbi.nlm.nih.gov/projects/mapview/map_search.cgi?taxid=9606&qrng=1&query=fragile+site

Answer 1

[tdmurphy]

Those fragile sites correspond to a set of fragile site records defined by HGNC, and imported into NCBI Gene: https://www.ncbi.nlm.nih.gov/gene/?term=txid9606%5Borgn%5D+genetype_other%5Bprop%5D+fragile+site%5Bgene%2Fprotein+name%5D

They're only defined by cytogenetic locations and aren't placed at the sequence level.

[rajesh]

Thanks, This information helps me alot..but some of these fragile site are also characterized at molecular level by FISH analysis.