two genes within same genomic region

Question

[mike]

Hello,

Gene 1:

NM_001003692 ZMAT5

chr22:30,126,945-30,163,000(GRCh37/hg19)

Gene 2:

NM_182527 CABP7

chr22:30,116,073-30,127,828(GRCh37/hg19)

Ref: http://www.genecards.org/

For these two genes, we see that, CABP7 is overlapping with ZMAT5, is this unusual? Thank you for any hint!

Answer 1

[WouterDeCoster]

That happens quite frequently so it's not too odd.

Answer 2

[michael.ante]

Hi Mike,

These two genes are on different strands of the chromosome. This is quite usual and nothing to worry about.

Cheers,

Michael

[mike]

Great. Thanks a lot!! What if a CpG site (DNA methylation) can map to two genes? I have seen this issue as well.

 ID        Genome_Build CHR UCSC_RefGene_Name
 cg27018124           37  22              HPS4
 cg27018124           37  22              SRRD

[Kevin Blighe]

A CpG site will affect transcription from both the sense and anti-sense strands.

Just to clarify, too: 2 different genes can be transcribed at the same position on both the sense and anti-sense strands, and also one can have overlapping genes on the same strand that have different TSS and/or promoters.