mapping between gene symbol and entrez ID

Question

[mike]

Hello,

I have mapped a few gene symbols to their entrez IDs using:

library(org.Hs.eg.db) 

info4gene = select(org.Hs.eg.db, symbols, c("ENTREZID"), "ALIAS")

where symbols are the gene names, such as 'NUDT10'.

As below, why are they some gene symbols can map to more than two entrez IDs?

ALIAS   ENTREZID

NUDT10  53343

NUDT10  170685

Is this usual to have many to many mapping? Is there a way to give only one to one mapping?

Thank you!

[mike]

https://www.ncbi.nlm.nih.gov/gene/?term=NUDT10 In this case 'NUDT10' one gene symbol can have many alias, even on different chromosomes (chrX, chr4). How should the decision be made?

[GenoMax]

53343 is NUDT9
170685 is NUDT10

[mike]

Yes, but NUDT10 is also the alias of 'NUDT9'. Also the command showed the same:

select(org.Hs.eg.db, "NUDT10", c("ENTREZID"), "ALIAS")

[GenoMax]

Can you not use the primary gene name (instead of the alias)?

[christopher medway]

Yes I think you should be using "SYMBOL" instead of "ALIAS"

[mike]

Thank you, that worked!