Are Provean-SIFT-results consistent with SIFT-original-results?

Question

[Mikee]

Hello,

Since I encountered problems on the mainpage of SIFT (http://sift.bii.a-star.edu.sg/) I wanted to know if the SIFT-predictions shown within PROVEAN are a correct substitute-source? (http://provean.jcvi.org/genome_submit_2.php?species=human)

This peculiar Question arises through my finding that I see different result-values for the same variant in different sites/programms (e.g. VariantEffectpredictor, VarSeq and so on). Maybe its due to different used freezes of SIFT? I see the same for Polyphen2-results.

Thank you very much for your help, kind regards, Michael

Answer 1

[Mikee]

Sorry, one correction: I ment Varsome not VarSeq, my bad

Answer 2

[prosium]

i got the error you said too. it's different sift-4G score and annovar-sift score. How would you do that?