Rna-Seq Bias: Conditional Quantile Normalization

Question

[Arun]

Hi,

I just skimmed through this post a couple of days back. It seems to be a method to correct the bias in the RNA-Seq data without loss using conditional quantile normalization. Has anyone ever tried this? Or have some idea about this? Seems interesting.

[Gww]

There's also this: http://genomebiology.com/content/12/3/R22

[Fred]

Is it for differential gene expression? If so, there is also this group that is looking at bias due to gene length and sequencing depth : http://bioinfo.cipf.es/aconesa/research3.html Their tool is called NOISeq