Comprehensive & integrated drug/target database?

Question

[sam237337]

The Drug2Gene resource integrates 19 different drug-target databases, and is distinguished by its standardization and unification across those different platforms (including ChEMBL, DrugBank, Uniprot, HGNC and ChEBI). However, when attempting to access this resource (http://www.drug2gene.com) for the past couple of weeks, it seems to be consistently unavailable. I'm wondering:

(a) Does anyone know the status of the Drug2Gene resource? Is it permanently defunct, or possibly, only temporarily unavailable due to upgrades?

(b) If Drug2Gene is no longer functional, is anyone aware of an alternative similar resource that integrates and standardizes across numerous drug-target resources?

Thanks for any insights you can share.

[Malachi Griffith]

This post discusses these databases extensively: A: Drug To Target/Gene/Protein Interaction Databases

Answer 1

[Denise CS]

Have you tried the Open Targets Platform? At the moment we use ChEMBL as a drug-target database and are looking into incorporating DrugBank and PubChem soon. In addition to drug information from ChEMBL, we use genetics and genomics as evidence to associate targets with diseases. These come from UniProt, GWAS Catalog, ClinVar, pathway databases, Genomics England, etc. For more details, head to the original Open Targets Platform paper, or check Open Targets, identifying targets for drug development in the treatment of diseases and Open Targets and programmatic access.

If you are interested in drugs affecting genes that are TF in cancer (e.g. nutlin-3a and TP53, note: scroll down on that page if you click on the link), check DoRothEA.

Finally Get to know LINK and explore 500+ million relations from PubMed abstracts and search for drug-target information extracted from PubMed abstracts.

Any questions or suggestions, please post them here or email us.

[sam237337]

Thanks for your helpful suggestions, Denise! I will definitely explore them.