Entering edit mode
6.7 years ago
Ghani
•
0
Is there anyone besides me who thinks it is foolish to label sites as Transversion or Transition. I mean what determines whether a site is a transition or transversion site since nucleotides are free to mutate to anything. For example if we have an A on the + strand (T - strand), then the A is free to mutate to C, G. or T ( although the mutation to G is more likely).
Calling a site a transversion site wrongly implies that the site is less likely to undergo a mutation than a transition site, however I don't see anything that would 'lock' the site to be a transversion site. Am I missing something?
Hello Ghani!
We believe that this post does not fit the main topic of this site.
MHO not related to bioinformatics. There are some good pointers in WP: https://en.wikipedia.org/wiki/Transversion
For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.
If you disagree please tell us why in a reply below, we'll be happy to talk about it.
Cheers!
It is most relevant to Bioinformatics since you always see reference made to Ti/Tv ratio as a quality control statistic in sequence processing.
You also have many researchers that use "transversion" only sites in downstream analysis because they think that those are more stable sites and less subject to mutations.
Therefore, it is important for everyone to know whether there are "transversion" only sites in the 1st place, and if so how to identify those sites in the genome, and what qualifies them to be transversion only sites.
The link you posted does not have any information on how to identify transversion only sites or what qualifies them to be so. Neither does anything else online that I am aware of.
It’s a useful question, thank you! See some details below:
https://www.mun.ca/biology/scarr/Transitions_vs_Transversions.html
http://www.differencebetween.com/difference-between-transition-and-vs-transversion/
https://www.quora.com/Why-are-transitions-more-common-than-transversions-in-DNA-mutations
Genetic example from Wiki:
https://genome.sph.umich.edu/wiki/SNP_Call_Set_Properties
7 years ago there was an interesting discission (post below):
Ti/Tv Ratio Confirms Snp Discovery. Is This A General Rule?