Replace read group

Question

[rse]

Hi,

I have multiple read groups in my bam file. I want to replace one read group and not the other. How should i proceed? Picard tools would replace all ? Will linux commands work?

[Devon Ryan]

Replace the read group information or name or swap it for a completely different dataset? The former two can be done simply by modifying the BAM header (you can reheader the file with samtools reheader then).