Protein classification system

Question

[Raghul]

Hi friends, There are several protein classification systems, each of them useful in a way! I want to study the thermophilic adaption of an organism at protein sequence & structure level (SEQUENCE & structure COMPARISON). Which of the available "protein groupings" could give better insights? I presume COG classification might be better! Or is it better to select certain type of proteins alone & finish the analysis? Any other suggestions for this study are welcome! If my question is not clear please inform me! Thanks!

Answer 1

[c.chakraborty]

Well your study is quite wide. Because, I am not sure you will find something, say motif or domain absolutely common to all proteins. You can pick a class, say polymerases, membrane proteins, metabolic pathway enzymes, and then study their topology, abundance and functional motifs. This way it would be easy, and feasible to assess.

[Raghul]

Thanks for the answer, This is what I am trying to do now! I am selecting enzymes,membrane proteins & proteins with hits to PDB.