How to predict the cellular origin of expression of a gene in a blood sample?

Question

[Joe Kherery]

Hello ladies and gentlemen,

I have a set of differentially expressed blood-derived genes from patients against healthy patients. So I wondered if there was a way to predict which cell type would most likely be expressing that gene? Example: monotics, eosinophils ...

Best,

Answer 1

[igor]

I am not sure you can do much with a single gene. However, you may want try cell type deconvolution which should give you the breakdown of different cell populations within your samples. These previous discussions have a few great suggestions:

• Deconvolution Methods on RNA-Seq Data (Mixed cell types)
• Deconvolution methods on RNAseq data

[Joe Kherery]

Thank you very much, it seems like this is what I really need.