Question

Gene Coding And Non-Coding Regions

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13.7 years ago

Babariqbal ▴ 10

Is non coding region of one gene can be the region of other gene?

gene intron exon • 4.5k views

ADD COMMENT • link updated 13.6 years ago by Larry_Parnell 16k • written 13.7 years ago by Babariqbal ▴ 10

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Not strictly a bioinformatics question, but relevant in bioinformatics analysis. Also, please try to think of more informative titles and tags for your questions than "molecular biology".

ADD REPLY • link 13.7 years ago by Neilfws 49k

score 8 · Answer 1 · 2011-06-02

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13.7 years ago

Neilfws 49k

I assume what you're trying to ask is whether a region which is an intron in one transcript can also encode an exon in a different transcript, either on the same strand or the opposite one.

The answer is yes: look at this view in the UCSC genome browser.

ADD COMMENT • link 13.7 years ago by Neilfws 49k

score 7 · Answer 2 · 2011-06-02

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13.7 years ago

Pierre Lindenbaum 165k

yes, http://en.wikipedia.org/wiki/Alternative_splicing

alt text

ADD COMMENT • link 13.7 years ago by Pierre Lindenbaum 165k

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Multiple alternative transcripts like those shown in the image are generally considered to all be part of the same gene. The question seems to be about different genes, though.

ADD REPLY • link 13.6 years ago by Eric Fournier ★ 1.4k

score 4 · Answer 3 · 2011-06-02

It could also be the 3'-UTR of one gene encodes either a UTR or protein-coding exon of another gene, on the same strand or on the opposite. What I find to be the most interesting examples are alternatively spliced mRNAs of the same gene where the UTR of one mRNA is a protein-coding segment of another mRNA for that same gene.