List of known fusions

Question

[Ron]

Hi all,

Is there any list of known fusions database besides the COSMIC data base ?

http://cancer.sanger.ac.uk/cosmic/fusion

Thanks,

Ron

Answer 1

[enxxx23]

It is not clear what kind of fusions are you looking for. Are you looking for fusions which are known also in healthy people, like for example MSMB-NCOA4, TTY15-USP9Y, SLC45A4-ELK4?

Here are very few: http://54.84.12.177/PanCanFusV2/ http://203.255.191.229:8080/chimerdbv31/mindex.cdb

For example, here are fusions which have been found in healthy people and most likely these fusions are false-positives? https://github.com/FusionAnnotator/FusionAnnotator/blob/master/Hg19_CTAT_fusion_annotator_lib/GTEx_Recurrent_Blacklist_July222016.txt

Answer 2

[pbpanigrahi]

Hi

I think you can explore FusionSearch module of FusionHub, a web server that allow you to annotate your fusion genes across 28 datasets in a single go. Databases include Cosmic, ChimerKB, ChimerPUB, ChimerSEQ, ChiTaRS, Farecafe, TicDB, Tumor Fusion Portal, FusionCancer, ConjoinG and some other datasets from literature. A total of 28 different fusion resources can be searched for fusion information.

Different ways you can search, pair-wise, gene-wise and chromosome-wise. Besides these annotation, the server allows you to annotate your fusion gene w.r.t functional domain, kegg/biocyc pathways, any possibility of non-coding gene fusion etc.

Hope this helps. Please provide your feedback/bug which will help to improve the tool.

Thanks

Priyabrata