To better understand how genotype and the environment determine phenotype, the Karr Lab is developing comprehensive whole-cell computational models which aim to represent all of the biochemical activity inside cells. In addition, we aim to use whole-cell models to advance medicine. Our research is interdisciplinary – involving systems biology, genomics, simulation, and software engineering – and team-oriented. We are seeking talented, ambitious individuals to join our team and help us develop tools for building, simulating, and analyzing comprehensive models of individual cells.
The Karr Lab is a member of the Icahn Institute for Genomics & Multiscale Biology at the Icahn School of Medicine at Mount Sinai which aims to combine genomics technologies with computational analyses to understand, diagnose, and treat disease. The Institute's interdisciplinary research spans genomics, systems biology, bioinformatics, and clinical informatics. Mount Sinai is a superb environment for translational research.
The Karr Lab is also a member the new NIH-funded Center for Reproducible Biomedical Modeling (http://reproduciblebiomodels.org) which aims to enable more predictive models of cells by making cell modeling systematic, scalable, and collaborative. The center includes Herbert Sauro and John Gennari at the University of Washington, Ion Moraru and Michael Blinov at the University of Connecticut Health Center, and David Nickerson at the University of Auckland.
Responsibilities
The scientists/engineers will work with our team and the Center for Reproducible Biomedical Modeling to develop an integrated database of biochemical and genomic data for modeling; tools for discovering data for modeling specific organisms; a framework for systematically designing models from large datasets; a universal simulator that can simulate a wide range of models including steady-state, logical, deterministic, stochastic, and spatial models; a database for simulation results; tools for mining large-scale simulation results; and web-based tools for visualizing models and simulation results. The scientists/engineers will also have opportunities to help build, simulate, and analyze models.
Desired skills/experience
Cell modeling is highly interdisciplinary. Consequently, we're looking for team members with a broad range of skills and experience.
- Passion for transforming medicine and bioengineering;
- Desire to tackle challenging problems and a commitment to innovation;
- Abilities to think creatively and integrate diverse concepts;
- Strong experience in modeling, software engineering, and/or visualization;
- Excellent oral and written communication skills;
- Abilities to work independently and within a team; and
- BS, MS, or PhD in computer science, applied math, or a related field.
Career development, compensation & benefits
Mount Sinai offers numerous opportunities for career development. Compensation will be commensurate with experience. All employees are eligible for medical, dental, and health insurance.
How to apply
Please send a cover letter describing your scientific/engineering interests and your CV to Jonathan Karr (karr@mssm.edu).
More information
Please visit our website (http://www.karrlab.org) or contact Jonathan Karr (karr@mssm.edu).
