What protein database would you use to analyze soil samples [Metaproteomics]?
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6.3 years ago
enriqp02 ▴ 30

Hello guys!

I've been involved in a new project, where I'm going to analyze proteins from different soils. However, I have not found any consortium where all the proteins studied are together, as for example in the human microbiota.

Could anyone tell me which database could be used? I have thought about NCBI nr, but the search would be very long computationally

soil metaproteomics • 1.4k views
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but the search would be very computationally tedious.

What do you mean by this? Are you sure "tedious" is the correct word here?

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Hahaha. Maybe yes or maybe not. Depend of the context. I said tedious because the search will take days or weeks... so it will be very boring haha. Probably I translated it directly from Spanish, where that phrase would have a better meaning ahaha.

Anyway, I just wanted to say that this process will take a lot of computational time

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If you want meaningful annotations, stick to SWISSPROT. NR isn't curated.

I've not used it previously, but this tool is supposedly much faster than NCBI's BLAST.

https://github.com/bbuchfink/diamond

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Thanks for your reply.

Anyway I'm going to use Mascot or Sequest search engines to looking for matches. I just want to know what is the best database to do this.

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Nobody with experience in this?

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Hi enriqp02,

I have moved your response to a comment as answer field is reserved for answers to the original question.

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