Simulating Trio Data

Question

[Ritu]

Which tool could be used to generate/simulate parents-offspring whole genome sequences (human) in accordance with a specified recombination rate?

Answer 1

[Len Trigg]

You could use the simulation tools available in RTG Tools. I would recommend running the demo-tools.sh script that comes as part of the package, as that steps through an end to end simulation of genomes of family members. You can then modify things from there according to your needs. In particular rtg childsim has the ability to adjust the overall recombination rate via --num-crossovers

[Ritu]

Thanks for the reference. I would try the tool's simulation.