Correlating putative enhancer elements with gene expression

Question

[rbronste]

I asked this question a while ago but given the fast moving field I was wondering what people thought about good approaches in correlating open chromatin and gene expression datasets from identical cell types and maybe inferring some relationship between putative regulatory regions and nearby genes? Thanks!

Answer 1

[Kristoffer Vitting-Seerup]

Based on expression alone this is very hard problem as illustrated by cases when people using correlation alone - which typically not performing much better than radome guessing (AUROC 0.5-0.6). I'm not aware of any good and available methods.