HTTP 400 error for select SNPs when using Ensembl Linkage Disequilibrium calculator

Question

[Scott]

Does anyone know why some SNPs return an error in the Ensembl LD calculator? Example SNPs include rs507666 and rs10423754. They appear to be valid SNP accessions in dbSNP but return an error in the calculator. When accessing programatically it is an HTTP 400; on the web interface it is "AJAX error - Runtime Error in component "EnsEMBL::Web::Component::Tools::LD::Results [content]""

Emily_Ensembl , can you help with this one?

Thanks!

[GenoMax]

Tagging: Emily_Ensembl and Ben_Ensembl

Answer 1

[Emily]

rs10423754 is flagged as suspect by dbSNP and rs507666 does not map to the genome. The error message is not particularly informative, so I'll try to get that changed.

[Scott]

Okay thanks. These are just a few examples. I expect to encounter dozens or a few hundred of these cases in my data set... Is there any way to obtain a list of SNPs (perhaps above a certain MAF threshold) that the LD calculator can handle, so that I can filter my list against them before LD calculation? Thanks for the assistance!

[Emily]

There is now a much more informative error message.

[Scott]

Thank you very much!