How plink calculates meta-analysis

Question

[johnS]

I am trying to find the logic/calculation what is used in plink to calculate the meta analysis when run the following command

plink --meta-analysis study1.assoc study2.assoc study3.assoc

I checked the plink website but dint find details http://zzz.bwh.harvard.edu/plink/metaanal.shtml . Could someone help me with the calculations that are happening in plink to come up with that single file after meta analysis ?

[zx8754]

From the plink 1.9 website:

• https://www.cog-genomics.org/plink/1.9/postproc#meta_analysis

Given multiple PLINK-format association reports, --meta-analysis performs basic fixed-effects and random-effects meta-analysis of the data, writing results to plink.meta.