Healthy controls - samples Illumina 450k methylation

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6.0 years ago

Adam ▴ 40

Hello,

I'd like to find some differentialy methylated tags of one particular disease, currently I'm using two databases:

https://xena.ucsc.edu/

https://portal.gdc.cancer.gov/

I found whole methylation profile (already normalized data) Beta values of dozens of samples. Nevertheless I can't find any cohort of healthy controls to perform some comparison of methylation level and get hipo- and hyper- methylated tags exclusively in my disease of interest. E.g. I choose gene DMD and actually I see it's methylation profile in patients with disease, promoter of this gene is hypermethyated, unfortunately I don't know if there is also high methylation in healthy controls?

Could you please provide me some ideas? Best Regards, Adam

methylation TCGA • 964 views

ADD COMMENT • link updated 6.0 years ago by Biostar 20 • written 6.0 years ago by Adam ▴ 40

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Can you provide direct links to the data and the published manuscripts pertaining to these?

ADD REPLY • link 6.0 years ago by Kevin Blighe 88k

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