Databases and Variant Tools for Cancer Genes

Question

[ojelizodun]

I am lost on how to get mutated variants of some cancer genes like BRCA1, BRCA2, BRIP1, PALB2, etc. Please, which database or tool should I explore? Thank you.

[WouterDeCoster]

It is unclear which data you have and what you aim to achieve, please elaborate.

[ojelizodun]

Alright. I only intend to know the available variants of each of these genes.I have accessed the main DNA sequences, but accomplishing the task of knowing their mutated variants is the help I need.
Thank you.

[WouterDeCoster]

Which "main DNA sequences"? What does that mean? You have to be more specific. Please elaborate. What are "the available variants"?

Answer 1

[Kevin Blighe]

...and remember that there is a difference between a somatic mutation and an inherited germline variant that increases your risk of cancer over your lifetime. Genes like the ones that you've listed are required for normal functioning of cells (BRCA1, BRCA2, are for DNA double-strand break repair) - they are associated with increased lifetime risk of cancer. Take a look at this previous answer: A: What's the difference between GWAS Catalog and COSMIC database ?

[ojelizodun]

Wahoo! These two databases should help, especially COSMIC. I will explore them. Thank you.