selection of disease relevant pathways after NGS

Question

[dentepre]

Hi, I need an advice. I work with rna-seq data obtained from intestinal cells from patients with IBD and healthy controls. I mapped raw reads to reference genome, obtained counts and performed differential expression procedures. As a results, I've obtained more that 200 genes, which expression is differ between disease affected and healthy cells. Now I am trying to establish the possible functional analysis. I've tryied to using KEGG, but it is very "molecular" - I need something more relevant to "disease" phenotype. Any advice for tool?

Thanks, d.

[GenoMax]

I suggest taking a look at Open Targets. Reactome is another option.

Then there is Ingenuity Pathway Analysis from Qiagen which is a rather pricey commercial option that has a lot of this specific information.