Entering edit mode
5.8 years ago
Firingam
▴
30
Hi everyone! I'm investigating about Low Complexity sequences in proteins but I have some problems chosing a Threshold that could actually helps to sunder when the LC content could influence the protein's behavior,e.g when i get a protein with five LC residues I would be prone to put that one in ~LC cluster. So the real question is, when do I have a content such to consider the LC presence significant in my sequence of AA?
Thank you in advance
See these posts, they may help you:
They show how to deal with LCR : some soft determines if the regions are LC-ones or not,
some mask them, etc.
Analysis Of Low-Complexity Regions
A: Masking Algorithms In Literature
A: Given Sequences, How To Compute A Low Complexity Score For Each Sequence?
How To Mask Low-Complexity Regions In Proteins?
Looking For Tools To Identify Low Complexity Regions In A Protein (Similar To Seg That Seems Unavailable)
A: Is There Any Script To Count Repeats In Protein Sequences?
Given Sequences, How To Compute A Low Complexity Score For Each Sequence? - this is almost answer to your question.
Complex Genomic Regions - see algorithms at the bottom of the post.
masking low complexity regions in a protein database for BLAST - masking - is it a good idea or not?
I'll check it out!Thanks!