Strelka2 and single tumour sample

Question

[sbilobram]

Is there a variant calling tool for a single tumour sample in Strelka? That is there is NO matched Normal for the FFPE exome sample that I wish to find variants on.

Any Suggestions?

[sviatoslav.kendall]

I think you could probably run Strelka2's germline workflow to at least find variants that differ from your reference genome. https://github.com/Illumina/strelka/blob/v2.9.x/docs/userGuide/README.md#germline