Which should items consider to creste a dru-drug-gene interaction network?

Question

[carlos_marchi]

Hi,

Assuming there is a list of human genes. I would like to know what to consider creating a drug-drug interaction network where only drug selected based on their correspondence to the gene target.

Furthermore, what to consider in the relationships among the nodes (drugs) in the Network? Would it be the protein-protein interaction involved those gene list?

Other two important things should consider in these relationships: pharmacokinetics and pharmacodynamics. For example, Drug A may inhibit drug B effects? Are drugs A or B toxic?

Is there a list of adverse drug reactions? If so, there is a degree of drug toxicity?

Another question: which public database should consider? Initially, I thought of drug bank, drug central, dgidb, pharmadb, toxnet, akos, chemid.

Does can help me with some strategy, articles?

Thank very much!

Answer 1

[dselleno]

Carlos Send me your email and I'll send you a link to help. Thanks

[carlos_marchi]

Hi dselleno! That's my email: [e-mail] Thank you very much!