Gene function prediction

Question

[Pappu]

I am wondering if there is any good way to predict the function of a gene given the fact that hardly any literature exists on it.

[GenoMax]

Have you tried standard annotation tools to see if they give you a clue of what the gene may be? Or are you drawing a blank from that type of analysis?

[Pappu]

Nothing came out from uniprot go annotation.

[Kevin Blighe]

If you have the mRNA sequence of the gene, then use blastx to see to which other proteins in other species it aligns. If you get a 100% homology hit, for example, then you could easily infer function.