Entering edit mode
5.8 years ago
landscape95
▴
190
Hi everyone, has anyone experienced this issue, I have around a million SNPs to do the PRS but with PRSice, after clumping, I only have around 100k SNPs remain. I wonder what situation this could be, thanks. Your help is really appreciated!
Base file:
plink.stat
1133273 variant(s) observed in base file, with:
1133273 total variant(s) included from base file
Start performing clumping
257682 MB RAM detected; reserving 10 MB for clumping
Allocated 10 MB successfully
Number of variant(s) after clumping : 112953
Phenotype is a continuous phenotype
57767 sample(s) with valid phenotype
Did you use imputed data? Imputed SNPs tends to have high LD with eachother and as a result most of those SNPs will be removed after clumping.