Phasing genotype likelihood data and merging them with phased genotype calls data.
0
0
Entering edit mode
5.6 years ago
Mr Locuace ▴ 180

I have 3 sets of genotypes:

  1. A multiethnic panel of phased 1000G Phase 3 genotypes in IMPUTE2 format (.hap).
  2. Genotype likelihoods (GL) for 40 whole-genotypes of a population A in .vcf format (field FORMAT=GL)
  3. An array of about 600.000 SNP (30X coverage) from a population B, which is genetically close to A.

I'd like to impute the missing genotypes of B using phased genotypes from A as a reference population merged with the 1000G data. My problem is how to get phased genotypes from A given the genotype likelihood data, in order to merge them with the 1000G .hap data. I'd highly appreciate any suggestion on how to solve this or how to obtain good quality imputed genotypes from B. Many thanks.

phasing genotype likelihood genotype calls • 1.3k views
ADD COMMENT

Login before adding your answer.

Traffic: 1883 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6